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ChiRhoClin, Inc. Sponsored Secretin Studies for Diagnostic Use

New Secretin Studies

>>  July 2017    Trout AT1, Wallihan DB2, Serai S3, Abu-El-Haija M4.

Secretin-Enhanced Magnetic Resonance Cholangiopancreatography for Assessing Pancreatic Secretory Function in Children.
2017 Jul 7. pii:S0022-3476(17)30814-4. doi:10.1016/j.jpeds.2017.06.031. [Epub ahead of print]
>>  March 2017  Suenaga M1, Sadakari Y1, Almario JA1, Borges M1, Lennon AM2, Shin EJ3, Canto MI4, Goggins M5.
Using an endoscopic distal cap to collect pancreatic fluid from the ampulla (with video).
2017 Mar 1. pii:S0016-5107(17)30128-1. doi:10.1016/j.gie.2017.02.026. [Epub ahead of print]


>>  May 2011  Jowell P, Branch M, Fein S, Purich E, Kilaru R, Robuck G, Almada MS, Baillie J.

      Intravenous Synthetic Secretin Reduces the Incidence of Pancreatitis induced by
      Endoscopic Retrograde Cholangiopancreatography.

      Pancreas. 2011 May;40(4):533-539




Draganov P, Patel A, Fazel A, Toskes P, Forsmark C. (2005, July).

Prospective evaluation of the accuracy of the intraductal secretin stimulation test in the diagnosis of chronic pancreatitis.

Clin Gastroenterol Hepatol. 3(7):695-9.


Pollack BJ, Grendell JH.

 Where have all the dreiling tubes gone?

Am J Gastroenterol. 2006 Feb;101(2):356-9.


Stevens T, Conwell DL, Zuccaro G Jr, Van Lente F, Purich E, Khandwala F, Fein S.

A randomized crossover study of secretin-stimulated endoscopic and dreiling tube pancreatic function test methods in healthy subjects.

Am J Gastroenterol. 2006 Feb;101(2):351-5.


Hirschowitz BI, Simmons JL, Johnson LF, Mohnen J. (2004, Mar).

Risk factors for esophagitis in extreme acid hypersecretors with and without Zollinger-Ellison syndrome. 

Clin Gastroenterol Hepatol;2(3):220-9.


Moumakwa BA, Crawley CD, Purich E, Edinboro L, Karnes HT. (2005, Jan).

Use of capillary electrophoresis in drug quality assessment of synthetic porcine secretin.  Biomed Chromatogr. ;19(1):68-79.


Stevens T, Conwell DL, Zuccaro G, Van Lente F, Khandwala F, Purich E, Vargo JJ, Fein S, Dumot JA, Trolli P, O'Laughlin C.

Electrolyte composition of endoscopically collected duodenal drainage fluid after synthetic porcine secretin stimulation in healthy subjects.

Gastrointest Endosc. 2004 Sep;60(3):351-5.


Chey WY, Chang TM.

Secretin, 100 years later

J Gastroenterol. 2003;38(11):1025-35. Review.


Conwell DL, Zuccaro G Jr, Vargo JJ, Trolli PA, Vanlente F, Obuchowski N, Dumot JA, O'laughlin C.

An endoscopic pancreatic function test with synthetic porcine secretin for the evaluation of chronic abdominal pain and suspected chronic pancreatitis.

Gastrointest Endosc. 2003 Jan;57(1):37-40.


Devereaux BM, Fein S, Purich E, Trout JR, Lehman GA, Fogel EL, Phillips S, Etemad R, Jowell P, Toskes PP, Sherman S. 

A new synthetic porcine secretin for facilitation of cannulation of the dorsal pancreatic duct at ERCP in patients with pancreas divisum:a multicenter, randomized, double-blind comparative study.

Gastrointest Endosc. 2003 May;57(6):643-7.


New Advances in Preventing ERCP Induced Pancreatitis.


Secretin Imaging and Publications


Merkel E.

Secretin-Stimulated MRCP

Gastroenterology & Hepatology 2005 1(3)


Matos C, Bali MA, Delhaye M, Deviere J.

Magnetic resonance imaging in the detection of pancreatitis and pancreatic neoplasms. 

Best Pract Res Clin Gastroenterol. 2006 Feb;20(1):157-78


Gillams AR, Kurzawinski T, Lees WR.

Diagnosis of duct disruption and assessment of pancreatic leak with dynamic secretin-stimulated MR cholangiopancreatography.

AJR Am J Roentgenol. 2006 Feb;186(2):499-506.


Erturk SM, Ichikawa T, Motosugi U, Sou H, Araki T. 

Diffusion-weighted MR imaging in the evaluation of pancreatic exocrine function before and after secretin stimulation.

 Am J Gastroenterol. 2006 Jan;101(1):133-6.


Matos C, Coppens E.

[Chronic and inflammatory pancreatitis:role of cross-sectional imaging]

J Radiol. 2005 Jun;86(6 Pt 2):749-57; quiz 758. Review. French.


Merkle EM, Baillie J.

Exocrine pancreatic function:evaluation with MR imaging before and after secretin stimulation.

Am J Gastroenterol. 2006 Jan;101(1):137-8.


Bali MA, Sztantics A, Metens T, Arvanitakis M, Delhaye M, Deviere J, Matos C. 

Quantification of pancreatic exocrine function with secretin-enhanced magnetic resonance cholangiopancreatography:normal values and short-term effects of pancreatic duct drainage procedures in chronic pancreatitis. Initial results. 

Eur Radiol. 2005 Oct;15(10):2110-21. Epub 2005 Jul 1.


Czako L, Takacs T, Morvay Z, Csernay L, Lonovics J.

[Diagnostic value of secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP) after unsuccessful endoscopic retrograde cholangiopancreatography (ERCP)] 

Orv Hetil. 2004 Mar 7;145(10):529-34. Hungarian


Matos C, Winant C, Delhaye M, Deviere J.

 Functional MRCP in pancreatic and periampullary disease. 

Int J Gastrointest Cancer. 2001;30(1-2):5-18. Review


Hellund JC, Geitung JT, Meo AM, Angelsen JH, Munkvik M, Trondsen E, Buanes T. 

[Secretin stimulated magnetic resonance cholangiopancreatography in diseases of the biliary and pancreatic ducts]

Tidsskr Nor Laegeforen. 2002 Mar 10;122(7):691-4. Norwegian.


Manfredi R, Brizi MG, Tancioni V, Vecchioli A, Marano P.

Magnetic resonance pancreatography (MRP):morphology and function.

Rays. 2001 Apr-Jun;26(2):127-33. Review.


Manfredi R, Brizi MG, Costamagna G, Masselli G, Vecchioli Scaldazza A, Marano P.

Pancreas divisum and santorinicele:assessment by dynamic magnetic resonance cholangiopancreatography during secretin stimulation.

Radiol Med (Torino). 2002 Jan-Feb;103(1-2):55-64. English, Italian.


Czako L, Endes J, Takacs T, Boda K, Lonovics J.

Evaluation of pancreatic exocrine function by secretin-enhanced magnetic resonance cholangiopancreatography. 

Pancreas. 2001 Oct;23(3):323-8.


Matos C, Metens T, Deviere J, Delhaye M, Le Moine O, Cremer M.

Pancreas divisum:evaluation with secretin-enhanced magnetic resonance cholangiopancreatography.

Gastrointest Endosc. 2001 Jun;53(7):728-33.


Manfredi R, Costamagna G, Brizi MG, Spina S, Maresca G, Vecchioli A, Mutignani M, Marano P.

Pancreas divisum and santorinicele:diagnosis with dynamic MR cholangiopancreatography with secretin stimulation. 

Radiology. 2000 Nov;217(2):403-8.

Past Studies


 Somogyi L, Cintron M, Toskes PP. 

Synthetic porcine secretin is highly accurate in pancreatic function testing in individuals with chronic pancreatitis.

 Pancreas. 2000 Oct;21(3):262-5.


 Jowell PS, Robuck-Mangum G, Mergener K, Branch MS, Purich ED, Fein SH. 

A double-blind, randomized, dose response study testing the pharmacological efficacy of synthetic porcine secretin.

Aliment Pharmacol Ther. 2000 Dec;14(12):1679-84.


 Metz DC, Buchanan M, Purich E, Fein S.

 A randomized controlled crossover study comparing synthetic porcine and human secretins with biologically derived porcine secretin to diagnose Zollinger-Ellison Syndrome.

Aliment Pharmacol Ther. 2001 May;15(5):669-76. 


 Devereaux BM, Lehman GA, Fein S, Phillips S, Fogel EL, Sherman S.

Facilitation of pancreatic duct cannulation using a new synthetic porcine secretin. 

Am J Gastroenterol. 2002 Sep;97(9):2279-81.


Preliminary Observations of A Randomized 2-Way Crossover Study Comparing the Endoscopic Pancreatic Function Test (ePFT) with Secretin for Exocrine Pancreas Function With and Without Meperidine / Midazolam Sedation in normal Subjects. 



A randomized 2-WAY Cross-over Study Comparing the Effects Of Conscious Sedation and Analgesia On Exocrine Pancreas Function In Normal Healthy Subjects (HS)



A New Endoscopic Pancreatic Function Test (ePFT) Using Synthetic Porcine Secretin in the Evaluation of Chronic Abdominal Pain (CAP) and Suspected Chronic Pancreatitis (CP). An abstract from Digestive Disease Week, San Francisco 2002

Conwell.PDF file


National Institutes of Health (NIH) State of the Science conference Statement, Endoscopic Retrograde Cholangiopancreatography (ERCP) for Diagnosis and Therapy, January 14-16, 2002. 

NIH Conference.PDF file 

Other Clinical Studies for Investigational Drugs Synthetic Human and Porcine Secretin


Toda Y, Mori K, Hashimoto T, Miyazaki M, Nozaki S, Watanabe Y, Kuroda Y, Kagami S.

Administration of secretin for autism alters dopamine metabolism in the central nervous system.

Brain Dev. 2006 Mar;28(2):99-103. Epub 2005 Sep 15.


Coplan J, Souders MC, Mulberg AE, Belchic JK, Wray J, Jawad AF, Gallagher PR, Mitchell R, Gerdes M, Levy SE.

Children with autistic spectrum disorders. II:parents are unable to distinguish secretin from placebo under double-blind conditions. 

Arch Dis Child. 2003 Aug;88(8):737-9.


Levy SE, Souders MC, Wray J, Jawad AF, Gallagher PR, Coplan J, Belchic JK, Gerdes M, Mitchell R, Mulberg AE. 

Children with autistic spectrum disorders. I:comparison of placebo and single dose of human synthetic secretin. 

Arch Dis Child. 2003 Aug;88(8):731-6.


Molloy CA, Manning-Courtney P, Swayne S, Bean J, Brown JM, Murray DS, Kinsman AM, Brasington M, Ulrich CD 2nd.

Lack of benefit of intravenous synthetic human secretin in the treatment of autism. 

J Autism Dev Disord. 2002 Dec;32(6):545-51.


Unis AS, Munson JA, Rogers SJ, Goldson E, Osterling J, Gabriels R, Abbott RD, Dawson G.

A randomized, double-blind, placebo-controlled trial of porcine versus synthetic secretin for reducing symptoms of autism.

J Am Acad Child Adolesc Psychiatry. 2002 Nov;41(11):1315-21.


Sandler AD, Sutton KA, DeWeese J, Girardi MA, Sheppard V, Bodfish JW.

Lack of benefit of a single dose of synthetic human secretin in the treatment of autism and pervasive developmental disorder. 

N Engl J Med. 1999 Dec 9;341(24):1801-6.


A Randomized, Double-Blind, Placebo-Controlled Trial of Porcine Versus Synthetic Secretin for Reducing Symptoms of Autism.

Unis.PDF file


Raimondo M, Imoto M, DiMagno EP. 

Rapid endoscopic secretin stimulation test and discrimination of chronic pancreatitis and pancreatic cancer from disease controls.

Clin Gastroenterol Hepatol. 2003 Sep;1(5):397-403.


Additional publications will be posted as published.